QuickBiology News

Scientists from Seattle and Berlin have published an atlas on mouse embryonic development. In their study the researchers examined about two million cells, with the RNA of each cell labeled individually with a specially developed method termed sci-RNA-seq. Junyue Cao, Malte Spielmann and their colleagues describe, which cell types differentiate between days 9.5 and 13.5 of mouse embryonic development, and how they transform into organs. In total, the scientists were able to identify 38 different main cell types and over 500 subtypes. In addition, they described 56 developmental trajectories in organ development for different cell types. The researchers compiled their results in an online atlas and made them accessible to the public.Read More

Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms.
In this study, miRNA profiling by RNA-seq was performed in paired benign and malignant biopsies from 12 women at the extremes of the BMI distribution among 83 BC patients. Candidates were validated in all samples by qRT-PCR. Associations between miR-10b expression and validated target transcript levels, and effects of targeted manipulation of miR-10b levels in a primary BC cell line on proliferation and invasion potential, were explored.Read More