siRNA Array - Cancer Driver Genes set I, II and III

siRNA Array - Cancer Driver Genes I, II and III

Plate Design and Layout:


siRNA Array- Cancer Driver Genes and related pathways:

siRNA Array -Cancer Driver Genes set I

siRNA Array - Cancer Driver Genes set1

siRNA Target Gene Title Pathway
CD_Plate1-1 TP53 tumor   protein p53 DNA damage signaling,   cell cycle, apoptosis
CD_Plate1-2 PIK3CA phosphoinositide-3-kinase,   catalytic, alpha polypeptide AKT signaling
CD_Plate1-3 KRAS v-Ki-ras2   Kirsten rat sarcoma viral oncogene homolog Ras signaling
CD_Plate1-4 PTEN phosphatase   and tensin homolog (mutated in multiple advanced cancers 1) AKT signaling
CD_Plate1-5 ARID1A AT   rich interactive domain 1A (SWI-like) Chromatin remodeling
CD_Plate1-6 NRAS neuroblastoma   RAS viral (v-ras) oncogene homolog Ras signaling
CD_Plate1-7 RB1 retinoblastoma   1 (including osteosarcoma) Cell cycle
CD_Plate1-8 BRAF v-raf   murine sarcoma viral oncogene homolog B1 MAPK signaling
CD_Plate1-9 CDKN2A cyclin-dependent   kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Cell cycle
CD_Plate1-10 ERBB2 v-erb-b2   erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived   oncogene homolog (avian) EGFR signaling
CD_Plate1-11 ARHGAP35 glucocorticoid   receptor DNA binding factor 1 Glucocorticoid   receptor signaling
CD_Plate1-12 ATM ataxia   telangiectasia mutated DNA damage signaling,   cell cycle
CD_Plate1-13 CTNNB1 catenin   (cadherin-associated protein), beta 1, 88kDa Wnt signaling pathway
CD_Plate1-14 ARID2 AT   rich interactive domain 2 (ARID, RFX-like) Chromatin remodeling
CD_Plate1-15 CASP8 caspase   8, apoptosis-related cysteine peptidase Apoptosis
CD_Plate1-16 CDKN1B cyclin-dependent   kinase inhibitor 1B (p27, Kip1) Cell cycle
CD_Plate1-17 EGFR epidermal   growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene   homolog, avian) EGFR signaling
CD_Plate1-18 EP300 E1A   binding protein p300 Chromatin remodeling
CD_Plate1-19 ERBB3 v-erb-b2   erythroblastic leukemia viral oncogene homolog 3 (avian) EGFR signaling
CD_Plate1-20 FAT1 FAT   tumor suppressor homolog 1 (Drosophila) Hippo signaling
CD_Plate1-21 Mock transfection (Control)
CD_Plate1-22 Background (without cells)
CD_Plate1-23 Scrambled siRNA 
CD_Plate1-24 Fluorescent siRNA

siRNA Array -Cancer Driver Genes set 2

siRNA Array - Cancer Driver Genes set 2

siRNA Target Gene Title Pathway
CD_Plate2-1 FBXW7 F-box   and WD repeat domain containing 7 Notch   signaling
CD_Plate2-2 IDH1 isocitrate   dehydrogenase 1 (NADP+), soluble TCA   cycle
CD_Plate2-3 KMT2D myeloid/lymphoid   or mixed-lineage leukemia 2 Histone   methylation, lysine degradation, ESR1 coactivation
CD_Plate2-4 NF1 neurofibromin   1 (neurofibromatosis, von Recklinghausen disease, Watson disease) Ras   signaling
CD_Plate2-5 NFE2L2 nuclear   factor (erythroid-derived 2)-like 2 antioxidant   response element (ARE) activation
CD_Plate2-6 PIK3R1 phosphoinositide-3-kinase,   regulatory subunit 1 (alpha) AKT   signaling
CD_Plate2-7 SMAD4 SMAD   family member 4 TGFβ signaling
CD_Plate2-8 STAG2 stromal   antigen 2 Cell   cycle
CD_Plate2-9 ASXL1 additional   sex combs like 1 (Drosophila) RAR,   PPPARG activity
CD_Plate2-10 B2M beta-2-microglobulin MHC   class I antigen presentation, immunity, FGFR signaling
CD_Plate2-11 BCLAF1 BCL2-associated   transcription factor 1 Apoptosis
CD_Plate2-12 BCOR BCL6   co-repressor Transcriptional   corepressor, histone deacetylase activity
CD_Plate2-13 CREBBP CREB   binding protein (Rubinstein-Taybi syndrome) AMPK   signaling
CD_Plate2-14 CTCF CCCTC-binding   factor (zinc finger protein) TGFβ signaling
CD_Plate2-15 FGFR3 fibroblast   growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) FGFR   signaling, AKT signaling
CD_Plate2-16 HLA-A major   histocompatibility complex, class I, A MHC   class I antigen presentation, immunity
CD_Plate2-17 HRAS v-Ha-ras   Harvey rat sarcoma viral oncogene homolog Ras   signaling
CD_Plate2-18 KDM6A lysine   (K)-specific demethylase 6A Wnt   signaling
CD_Plate2-19 KMT2C myeloid/lymphoid   or mixed-lineage leukemia 3 Histone   methylation, lysine degradation
CD_Plate2-20 RASA1 RAS   p21 protein activator (GTPase activating protein) 1 Ras   signaling
CD_Plate2-21 Mock transfection (Control)
CD_Plate2-22 Background (without cells)
CD_Plate2-23 Scrambled siRNA 
CD_Plate2-24 Fluorescent siRNA

siRNA Array -Cancer Driver Genes set 3

siRNA Array - Cancer Driver Genes set 3

siRNA Target Gene Title Pathway
CD_Plate3-1 SETD2 SET   domain containing 2 Histone   methylation, lysine degradation
CD_Plate3-2 SMARCB1 SWI/SNF   related, matrix associated, actin dependent regulator of chromatin, subfamily   b, member 1 Chromatin   remodeling
CD_Plate3-3 AKT1 v-akt   murine thymoma viral oncogene homolog 1 AKT   signaling
CD_Plate3-4 COL5A1 collagen,   type V, alpha 1 Collagen   biosynthesis, Integrin pathway, ERK signaling
CD_Plate3-5 ELF3 E74-like   factor 3 (ets domain transcription factor, epithelial-specific ) EGFR1   signaling
CD_Plate3-6 EZH2 enhancer   of zeste homolog 2 (Drosophila) DNA   and histone methylation
CD_Plate3-7 EZR ezrin Proteoglycans   in cancer, Regulation of actin cytoskeleton, RhoA signaling
CD_Plate3-8 KEAP1 kelch-like   ECH-associated protein 1 Ubiquitin   mediated proteolysis, oxidative stress induced gene expression via Nrf2
CD_Plate3-9 MAP3K1 mitogen-activated   protein kinase kinase kinase 1 MAPK   signaling pathway
CD_Plate3-10 MGA MAX   gene associated MYC-MAX   repressor
CD_Plate3-11 MYD88 myeloid   differentiation primary response gene (88) Toll-like   receptor signaling pathway
CD_Plate3-12 NCOR1 nuclear   receptor co-repressor 1 Thyroid   hormone signaling, RAR signaling, Notch signaling
CD_Plate3-13 NOTCH1 Notch   homolog 1, translocation-associated (Drosophila) Notch   signaling
CD_Plate3-14 PBRM1 polybromo   1 Chromatin   remodeling
CD_Plate3-15 PTPN11 protein   tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) IL6   signaling, IGF signaling
CD_Plate3-16 RAC1 ras-related   C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Ras   signaling, MAPK signaling, AKT signaling
CD_Plate3-17 RUNX1 runt-related   transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) Acute   and chronic myeloid leukemia, TGF-beta signaling
CD_Plate3-18 SETDB1 SET   domain, bifurcated 1 Lysine   degradation, Noncanonical Wnt signaling, Chromatin regulation/Acetylation
CD_Plate3-19 SF3B1 splicing   factor 3b, subunit 1, 155kDa Spliceosome,   mRNA splicing/processing
CD_Plate3-20 SMARCA4 SWI/SNF   related, matrix associated, actin dependent regulator of chromatin, subfamily   a, member 4 Chromatin   remodeling, BRCA1 signaling, AMPK signaling
CD_Plate3-21 Mock transfection (Control)
CD_Plate3-22 Background (without cells)
CD_Plate3-23 Scrambled siRNA 
CD_Plate3-24 Fluorescent siRNA