Drug Array plate design and layout

Drug Array Plate Design and Layout:

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Drug Array targeted genes and pathways:

Array 1: Apoptosis, Cell cycle, Cytoskeleton, DNA damage, HDAC.

Array 2: Kinase signaling pathways (MEK-ERK, MTOR-S6, NF-κB, NRTK, PAK, PI3K-AKT, PRKC),NOTCH and TNFα signaling pathways.

Array 3: Rac GTPases, Retinoic acid X family, RTK, SMO,Protein modifications, Metabolism.


Drug Array I
Drug Array II
Drug Array III
Drug Name Targets Pathway Drug Name Targets Pathway Drug Name Targets Pathway
1 ABT-263 BCL2,   BCL-XL, BCL-W Apoptosis 1 AZ628 BRAF MEK-ERK 1 QS11 ARFGAP Rac   GTPases
2 PAC-1 CASP3   activator 2 SP   600125 JNK1,2,3 2 EHT 1864 Rac GTPases
3 Embelin XIAP 3 AZD6244 MEK1/2 3 ATRA Retinoic   acid and RXR agonist Retinioic   acid X family
4 ZM-447439 AURKB Cell   cycle 4 GW   441756 NTRK1 4 Dasatinib ABL,   SRC, KIT, PDGFR RTK
5 CGP-60474 CDK1/2/5/7/9 5 BIRB   0796 p38,   JNK2 5 NVP-TAE684 ALK
6 PD-0332991 CDK4/6 6 CCT007093 PPM1D 6 VX-680 Aurora A/B/C,   FLT3, ABL1, JAK2
7 JNJ-26854165 MDM2 7 NSC-87877 SHP1/2   (PTN6/11) 7 LFM-A13 BTK
8 BI-2536 PLK1/2/3 8 Torin   1 MTOR MTOR-S6 8 BIBW2992 EGFR, ERBB2
9 Tipifarnib Farnesyl-transferase   (FNTA) 9 PF-4708671 p70   S6KA 9 PD-173074 FGFR1/3
10 S-Trityl-L-cysteine KIF11 10 KIN001-135 IKKE NF-KB 10 CEP-701 FLT3, JAK2,   NTRK1, RET
11 SL   0101-1 RSK,   AURKB, PIM3 11 Parthenolide NFKB1 11 BMS-536924 IGF1R
12 PF-562271 FAK Cytoskeleton 12 BMS-708163 gamma-secretase NOTCH 12 PF-02341066 MET, ALK
13 GSK269962A ROCK1 13 DAPT g-secretase 13 WH-4-023 SRC family, ABL
14 Docetaxel Microtubules 14 GNF-2 BCR-ABL NRTK 14 BAY 61-3606 SYK
15 KU-55933 ATM DNA   Damage 15 BMX-IN-1 BMX 15 Pazopanib VEGFR, PDGFRA,   PDGFRB, KIT
16 AZD7762 CHK1/2 16 BMS-509744 ITK 16 Cyclopamine SMO SMO
17 ABT-888 PARP1/2 17 IPA-3 PAK PAK 17 Elesclomol HSP70 Protein   modification
18 Camptothecin TOP1 18 A-443654 AKT1/2/3 PI3K-AKT 18 17-AAG HSP90
19 Etoposide TOP2 19 OSU-03012 PDK1   (PDPK1) 19 Bortezomib Proteasome
20 NU-7441 DNAPK 20 NVP-BEZ235 PI3K   (Class 1) and mTORC1/2 20 DMOG Prolyl-4-Hydroxylase
21 Salubrinal GADD34-PP1C   phosphatase 21 Staurosporine PRKC PRKC 21 AICAR AMPK   agonist Metabolism
22 Vorinostat HDAC   inhibitor Class I, IIa, IIb, IV HDAC inhibitor 22 Lenalidomide TNF   alpha TNF alpha 22 Methotrexate Dihydrofolate   reductase (DHFR)
23 DMSO   (with cells) - (Control) 23 DMSO   (with cells) - (Control) 23 DMSO (with cells) - (Control)
24 DMSO   (without cells) - 24 DMSO   (without cells) - 24 DMSO (without   cells) -